W dniu 16.09. o godz. 1000 w sali im. Olszewskiego odbędzie się wykład pt.
„Impact of the gastrointestinal passage of nanoparticles
on drugs’ absorption: focus on insulin”
prof. António J. Ribeiro
Faculdade de Farmácia, Universidade de Coimbra, Coimbra, Portugal
I3S – Instituto de Investigação e Inovação em Saúde, Porto, Portugal
Oral administration of drugs is recognized as the safest and most attractive, however oral bioavailability can be hampered by the gastrointestinal (GI) low stability tract and intestinal low permeability of drugs. Nanoencapsulation is a promising approach to overcome most of these drawbacks. The impact of the GI environment on the aggregation of biopolymer-based nanoparticles (NP) and its further influence on insulin release and permeability at the cellular level, was investigated in vitro. NPs were able to significantly increase the permeability of insulin across the cell-based engineered intestinal models, further enhanced by the presence of a mucus layer and M-like cells and a correlation between the size behavior of NPs upon passage in the GI tract and both insulin release profile and permeation across intestinal in vitro models was addressed. There was evidence that the GI passage of NPs has a major influence on the oral absorption of macromolecules such as insulin.