Science
Pharmaceutical science is a discipline encompassing the design of active molecules, their synthesis, analysis, through the development of innovative drug forms, (pre-)clinical trials, to the legal aspects related to their implementation and marketing.
At the Faculty of Pharmacy of the Medical University of Warsaw, we are involved in nearly 50 research and development projects worth over PLN 47 million.
A summary of these is available here
Our achievements:
As a result of scientific research conducted in the Microbiota Lab, employees have attempted to commercialise a post-biotic metabolite of urolithin A as a potential new drug for atopic dermatitis administered as an ointment or cream.
Staff in the Department of Medicinal Chemistry have developed LC-MS/MS methods for the determination of tacrolimus, a calcineurin inhibitor, in both liver and kidney tissue, as well as in its free fraction.
In the Department of Drug Technology and Pharmaceutical Biotechnology, innovative selective immunosuppressants with selenopolysaccharide structures were obtained by biosynthesis, and methods for their preparation, isolation and extended pharmacological testing were developed.
The staff of the Department of Drug Technology and Pharmaceutical Biotechnology are co-authors of the concept of inhibition of the formation of the PEX14 and PEX5 protein complex as a new strategy in the treatment of parasitic diseases. This research was the basis for the prestigious Erwin Schroedinger Preis scientific award for one of our scientists.
In the Department of Drug Technology and Pharmaceutical Biotechnology, an inhaled theranostic formulation was developed for the delivery and monitoring of the distribution in lung tissue of anti-tuberculosis drugs. A method for contrasting MRI images of lung tissue was developed. An integrated methodology for monitoring mass transport within matrix tablets during drug release was developed.
In the Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, the structures of two new bioactive compounds cinoglossol and rinderol were identified in root cultures of Cynoglossum columnae Ten.
In the Department of Pharmaceutical Biology and Medicinal Plant Biotechnology, a bifunctional platform using organosilicon aerogel reinforced with non-woven fabric in in vitro cultures of Rindera graeca transformed roots was developed for simultaneous biomass immobilisation and in situ extraction of naphthoquinones with cytotoxic properties.
In the Department of Applied Pharmacy, a surgical navigation system for cancer treatment supported by fluorescence imaging based on fluorescence excitation of cells labelled with rAAV gene formulations was developed.
In the same Department, an emulsion formulation with increased viscosity was developed for the topical introduction of steroidal anti-inflammatory drugs in children.
Employees of the Department of Physical Chemistry discovered a new crystalline form of 17-β-estradiol and developed a method for its preparation (patent 423041).
In the same Department, a method was developed for radical analysis using the EPR technique in an in vivo model of Danio rerio embryos ( PCT/IB2021/055356).
In the Department of Analytical Chemistry, new calcium phosphates enriched in selenate IV ions (hydroxyapatites, bruschetta) were synthesised.
The staff of the Department of Analytical Chemistry also developed new inorganic-organic composites for potential applications in the treatment of bone disorders.
In the same department, new carriers were developed for the intrathecal administration of drugs used in the treatment of bone disorders (simvastatin, bisphosphonates, raloxifene).